I would say it is already working with most major applications. I think it works with Photoshop and it certainly works with all of the Office applications.
I bet it won't work if you embed an .eps file in a Word document. Word is known to push those directly to postscript printers. Probably uses the same escape as Acrobat. On non-ps printers it normally only prints the low-resolution preview, and only if one came with the .eps.
Cheers, Kuba