Debian's Wine packages build with --without-mingw.
See debian/rules in: http://deb.debian.org/debian/pool/main/w/wine/wine_5.0.3-3.debian.tar.xz
If I remember correctly this increases the chance of not being able to run applications that expect specific binary layouts for Windows function prologues, i.e. mostly those with copy-prevention / anti-cheat schemes.
If so packages that needlessly disable MinGW are doing their users a disservice and are not presenting Wine in its best light.
Do I remember correctly? Should packagers be advised not to compile without MinGW?