A few comments from an outsider:
* Looks very Web 2.0-ish. Gradients, glossiness, rounded corners, dark background. You might want to tune it down slightly to make it look more polished. But this may just be my personal dislike for Web 2.0 designs.
* I am missing an introductory text. It should be really short, like: "Wine lets you run Windows programs on Linux and the Mac, so you don't need to buy Windows." (Addendum: That introduction in the latest relayout is too technical and long.)
* About the big links: great! WineHQ was always hard to navigate, but this is really nice! The grey text is a little hard to read though. I think it wouldn't hurt the overall readability if the contrast was a little higher, say #777 or even #555. The smaller size already does the job of making that text secondary to the links.
* I really liked the random screen-shots that showed what Wine could do. Maybe it could be worked back into the new design at the bottom of the page? Something like: "Wine can run many programs, including these:" And then three screen-shots with a caption that says which program it is. Those then link to their respective AppDB pages. It could be too much clutter though.
Remco