Watching Twitter, one fairly frequently seems people trying and failing to run iTunes 10 and the like in Wine.
Should we let them bash their heads against the wall like that?
Maybe we should detect the top ten apps that don't work with Wine, and put up a warning dialog saying they are known not to work, and people shouldn't try. (Kind of like what Windows 7 does when you do something dangerous, e.g. try to look at the contents of drive C:.)