What I think was being asked if you could use Winelib to build a native linux application that just uses wine for libraries (similar to gtk and other libs). In the case of wine your executable becomes a library which needs to be run by wine. Further you need other wine stuff (registry settings, c: drive ..). I'm not talking about the GUI.
there is ongoing work to make wine usable as a shared library, at least in some contexts.
--p