I just ran into http://www.ccp14.ac.uk/solution/wine/ which lists about ten free Windows apps used for crystalography, and how to run them under Wine.
I guess these deserve an appdb entry; they don't seem to have one yet.
That page describes workarounds needed to run with Wine as of about three years ago. Things may have progressed since then. For instance, the "you must rename files to have lower case" workaround no longer seems neccessary for the INDX program. I wrote the maintainer about that, haven't heard back from him yet. - Dan