The last version of wine I tried this game with was before the ddraw rewrite and it looked fine then. When you drag goo upwards, a text message appears telling you how many meters high your tower is -- this is now drawn upside down.
You can get tower of goo for free here:
http://www.experimentalgameplay.com/game.php?g=1
The sound also seems really messed up but before I was playing with it off so I don't know if that's a regression.