I've seen conflicting reports about whether Wine is safe to run on SMP systems.
Have the issues described in http://www.winehq.org/hypermail/wine-devel/2005/01/0060.html been taken care of?
I just pinged the reporter of the only bug with SMP in the summary, http://bugs.winehq.org/show_bug.cgi?id=2708 to see if he can still reproduce it. - Dan