I've met this kind of errors so many times with fresh installs that I finally took a look at what was going on; err:winecfg:set_config_key Unable to set configuration key Audio in section Drivers, res=1021
This error occurs because HKCU\Software is created with REG_OPTION_VOLATILE, thus making it impossible to create non-volatile keys under HKCU\Software. This breaks about every app that's trying to create keys under "Software" - like winecfg.
This is because SystemParametersInfoW in dlls/user/sysparams.c creates the "HKCU\Software\Wine\Temporary System Parameters" key with REG_OPTION_VOLATILE - and if you do not have HKCU\Software\Wine already available, they are crated as volatile also. ( see get_volatile_regkey() )
You can test this simply by (if you have a fresh install, you can go directly to 4.); 1. Opening regedit 2. Delete HKCU\Software (or HKCU\Software\Wine only) 3. Close regedit 4. Open regedit 5. Try to create a new key under HKCU\Software (or HKCU\Software\Wine, if you removed only that) 6. You'll get error message "Subkey must be volatile"
Any comments?
( This could be fixed in sysparams.c - already got a patch ready for it, but probably it's better to ensure in wineserver that the Software\Wine exists or something, so that this bug does not pop up again later? )