Thanks to a few targeted patches written by Stefan Siebert and James Hawkins, and of course decades of effort by the whole Wine team, Lotus Notes 7 trial version now installs and runs! See http://wiki.winehq.org/LotusNotes for details.
I just spent an hour or so playing with Notes as a plain old email client. It had a few mysterious crashes, but in general seemed usable. (Not that I'd ever use it after getting used to gmail, but that's another story.) I filed bug http://bugs.winehq.org/show_bug.cgi?id=5752 about a strangeness in the email client. - Dan