The Sony rootkit fiasco alone should be enough to end this conversation.
Period.
Say what you want about the theoretical integrity of the media, and the user's security habits. The fact is that hundreds (possibly thousands or millions) of _real_ people were infected by rootkits because of autorun and an unscrupulous corporation.
As you've so aptly demonstrated, average users are all too willing to trust people who don't deserve to be trusted. If Wine can protect some of those people sometimes, great. If Wine can protect people without any developers having to do any work, that's simply amazing.
Well done Wine devs.
--tim