dbghelp supports both linux debug formats (stabs, dwarf) as well as microsoft's one so any debugger using dbghelp as it's debug info provide should debug with all bells & whistles native & builtin applications I had some success with windbg (with a an 'e' between n & d ;-)
unfortunately, http://www.winehq.org/site/docs/winedev-guide/dbg-others isn't fully uptodate A+