Scott W Gifford gifford@umich.edu writes:
CreateFileW identifies the file as starting with backslashes and a dot, and in files/file.c:358 it uses RtlIsDosDevice to determine whether it's a DOS device name. RtlIsDosDevice returns 0, so at line 360 Wine tries to open \.\COM1 as a VxD.
Try a more recent Wine.