I just improved http://code.google.com/p/winezeug/source/browse/trunk/install-wine-deps.sh so it does all the futzing needed to build 32 bit wine on 64 bit systems (although at the moment it only does this for Ubuntu Intrepid).
Because it puts the missing .so files in /usr/lib32, there's no need to futz with LDPATH.
For example, after running the script, you can do either ./configure make to build 64 bit wine, or ./configure --target=i686-unknown-gnu-linux make to build 32 bit wine. Easy beans! - Dan