From: "Nadgir, Ananth P" ananth.p.nadgir@intel.com
Does Wine now support executing x64 bit PE executable like winnt32.exe under amd64 directory?
No, the biggest problem is that the 64-bit calling conventions are different between PE executables and Linux executables. Some more info on the Wine64 wiki page http://wiki.winehq.org/Wine64
Ge van Geldorp.