I know that for a while there were some packaging problems that meant that upgrading to 12.04 made compiling 32-bit Wine on a 64-bit PC extremely difficult.
I was able to patch and build 32-bit wine on 64-bit 12.04, using a debootstrap chroot:
https://help.ubuntu.com/community/DebootstrapChroot/
Setting up the chroot took a couple of minutes, and was trivial to do.
However, there appears to be a bug in wine or ubuntu which prevents SW:TOR from forking the display process, so I can't actually use wine on 12.04 to play the game I want. But building custom wine works fine.
cheers,
Joey