well, it has to be further checked. I'd say likely (as it's possible with MFC)
May there be any other problems than with source-compiler ones ? It is quite old lib and I wouldn't expect it to use any "new" windows api features. Much less than current MFC - I am sure.
my main concern isn't against API support (some native OWL should run in wine). it's more compilation issues that we may face (like use of pragma, specific preprocessor extents..., some 32/16 bit discrepencies). Compiling MFC under wine is not a piece of cake (and furthermore, details have never been released because of copyright issues)
Going back to the OWL sources & wine ;-) (And getting some beer as it is late evening in Poland now ;-)
don't code and drink ;-)
A+