I've been posting my findings on this very matter to wine-users - look for "cannot run under Fedora 6 tset 1".
I have also found that, if you are running in an SELinux system, you cannot directly run a Windows program using binfmt_misc - the program must have the same security context labels set as the Wine executables do.
And on my system, wine-pthread and wine-kthread both have the wine_main_preload_info symbol exported - only the actual "wine" executable lacks this. Directly running wine-pthread works for me for simple Windows programs, however installers don't work as the temporary executable created by the installer a) does not have the correct security tags and b) is passed directly to "wine" not wine-pthreads.