Fedora includes now a 64-bit Wine package (at least in F11) which of course breaks existing Wine setups. "yum install wine" will install the 64-bit version... Looks like we had our WineConf too late for this.
I have opened https://bugzilla.redhat.com/show_bug.cgi?id=533988 for this problem.
The quick fix is to just remove the wine*.x86_64 rpms and install the wine*.i586 instead.
bye michael