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Sorry this is a little off topic from D3D but maybe what the OP is looking for.
I'm not sure how easy it is but .net 3.5 sp1 is currently a blocker for several high profile games that would otherwise work well with Wine, and many others that may work. .net needs to install correctly and function well enough so that generic .net game lunchers run and (importantly) Games for Windows Live runs and authenticates. GFWL is what many of these games rely on and it is currently blocked by .net so it's unknown how well it runs under Wine but it does install properly.
This maybe suited to a GSoC project and in my opinion would have the greatest positive outcome for gamers.
Edward