Is anyone working on implementing FindFirstChangeNotification and friends? If not, this looks like something that may be both within my capabilities and non-trivial enough to be useful (a rare combination!).
My thought is to use SGI FAM (http://oss.sgi.com/projects/fam/), which is shipped with Red Hat and (according to bug #588) Mandrake. I'm not sure about any other distributions, but the FAQ on the web page states that Enlightenment, GNOME, and KDE all use it, so it should be pretty widespread.
If no one is working on this, start preparing for an endless series of questions about the wineserver's internal workings.