Microsoft has announced a feature complete preview of .NET 5.0: https://devblogs.microsoft.com/dotnet/announcing-net-5-0-preview-8/
I thought I would pre-empt the inevitable questions about what this means for Wine and Wine Mono. The answer is, not very much.
Summary: Wine Mono will only replace .NET version 4.x and earlier. For .NET 5.0 and later in Wine, the official binaries from https://dotnet.microsoft.com/download/dotnet/5.0 should be used. The 2 runtimes can be installed at the same time and will function independently.
.NET 5.0 does not interact with earlier versions of .NET at all, nor is it really part of the OS. It is a runtime that can be installed globally, or packaged with an individual application, similar to how the Mono runtime functions on Windows now. I have been told that it works fine in Wine. It's also (mostly) open source.
Since .NET 5.0 breaks compatibility with earlier versions (winforms has removed APIs and changed the default font which breaks some application layouts), is open source, works independently from .NET 4.x and earlier, already works in Wine, and has a build system very different from the one used in Wine Mono, it does not make sense to try to replace it with Wine Mono. Should Wine require any changes that upstream does not wish to merge, we will need our own fork, otherwise we can simply use the official binaries.
One reason to fork it might be to remove dependencies on proprietary components, most notably PresentationNative_cor3.dll, and Microsoft SDK build tools. Some of the work I've been doing with WPF may help with that, but it's still incomplete and would need to be forward-ported to the current version of WPF.
For folks who want to use Wine to port Windows applications using .NET 5.0 winforms or wpf to other platforms, I am not aware of anything in the .NET 5.0 license that would get in the way of this use case.