Two years ago I tried building wine with the LSB development kit, http://www.winehq.org/pipermail/wine-devel/2006-August/050554.html They've released a snazzy new beta of LSB 4.0, see https://www.linuxfoundation.org/en/LSB_4.0_Beta
Could somebody try building and running Wine with it to give them feedback? I'll give it a try myself sometime, but I'm pretty busy...