http://bugs.winehq.org/show_bug.cgi?id=23150
--- Comment #7 from Austin English austinenglish@gmail.com 2010-06-13 12:57:49 --- (In reply to comment #6)
I've heard that using the launcher causes there to be no sound in the game. Have you tried bypassing the launcher? That's how I run it in Linux, and might explain why I never had this particular sound problem.
Yeah, that makes a difference, but only if you're in a virtual desktop:
no VD, using launcher: no sound no VD, using masseffect2.exe: no sound VD, using launcher: no sound VD, using masseffect2.exe: sound
however, using the virtual desktop then gives you bug 23127, and makes controlling the mouse harder..